Hi moonfriend, I'm left handed and I had this problem with many KDE distros (Sabayon Mini, DesktopBSD, many LiveCD), but never with Gnome.
These settings are stored in
you can open it with text editor and modify the string
<entry name="left_handed" mtime="1234668533" type="bool" value="true">
setting "true" as value.
Say me if it runs.